Assessment of quality of life in Mexican patients suffering from chronic venous disorder - impact of oral Ruscus aculeatus-hesperidin-methyl-chalcone-ascorbic acid treatment - 'QUALITY Study'

Phlebology. 2009 Aug;24(4):157-65. doi: 10.1258/phleb.2009.008066.


Objectives: The present study assessed the effect of Ruscus aculeatus-hesperidin-methyl-chalcone-ascorbic acid (HMC-AA) on the quality of life (QoL) of patients suffering from chronic venous disorders (CVDs).

Methods: An observational, multicentre and prospective study was performed with 917 Mexican patients suffering from CVD. Patients were treated with R. aculeatus-HMC-AA. After 12 weeks of treatment, the physicians then assessed the patients' symptoms and QoL using Short Form (SF-12) and Chronic Venous Insufficiency (CIVIQ) auto-questionnaires.

Results: Patients were mainly women (86.7%), overweight or obese (72.7%) or C2 (39.3%)-C3 (27.6%). All symptoms and ankle circumferences significantly improved over time, with increasing clinical, aetiological, anatomical and pathophysiological (CEAP) classes and body mass index (BMI) (P < 0.001). Concerning QoL, all dimensions of the SF-12 score significantly improved over time (P < 0.001). Moreover, the CIVIQ scores significantly improved (P < 0.001) with increasing BMI (P < 0.002) and CEAP classes (P < 0.05).

Conclusion: R. aculeatus-HMC-AA significantly improved the symptoms and QoL of CVD patients.

Publication types

  • Clinical Trial
  • Multicenter Study

MeSH terms

  • Administration, Oral
  • Adult
  • Ascorbic Acid / administration & dosage*
  • Body Mass Index
  • Chalcone / administration & dosage*
  • Chronic Disease
  • Drug Therapy, Combination*
  • Female
  • Hesperidin / administration & dosage*
  • Humans
  • Male
  • Mexico
  • Middle Aged
  • Obesity / complications
  • Plant Extracts / administration & dosage
  • Prospective Studies
  • Quality of Life
  • Ruscus / metabolism*
  • Surveys and Questionnaires
  • Vascular Diseases / drug therapy*
  • Vascular Diseases / ethnology
  • Vascular Diseases / psychology*


  • Plant Extracts
  • Chalcone
  • Hesperidin
  • Ascorbic Acid