Genetic variants at 6p21.33 are associated with susceptibility to follicular lymphoma

Nat Genet. 2009 Aug;41(8):873-5. doi: 10.1038/ng.419. Epub 2009 Jul 20.


We conducted genome-wide association studies of non-Hodgkin lymphoma using Illumina HumanHap550 BeadChips to identify subtype-specific associations in follicular, diffuse large B-cell and chronic lymphocytic leukemia/small lymphocytic lymphomas. We found that rs6457327 on 6p21.33 was associated with susceptibility to follicular lymphoma (FL; N = 189 cases, 592 controls) with validation in another 456 FL cases and 2,785 controls (combined allelic P = 4.7 x 10(-11)). The region of strongest association overlapped C6orf15 (STG), located near psoriasis susceptibility region 1 (PSORS1).

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosomes, Human, Pair 6 / genetics*
  • Genetic Predisposition to Disease*
  • Genetic Variation*
  • Humans
  • Lymphoma, Follicular / genetics*
  • Lymphoma, Large B-Cell, Diffuse / genetics
  • Polymorphism, Single Nucleotide / genetics