Regulation of Wnt/beta-catenin signaling by protein kinases

Dev Dyn. 2010 Jan;239(1):34-44. doi: 10.1002/dvdy.22019.

Abstract

The Wnt/beta-catenin signaling pathway plays essential roles during development and adult tissue homeostasis. Inappropriate activation of the pathway can result in a variety of malignancies. Protein kinases have emerged as key regulators at multiple steps of the Wnt pathway. In this review, we present a synthesis covering the latest information on how Wnt signaling is regulated by diverse protein kinases.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Axin Protein
  • Embryonic Development / physiology*
  • Gene Expression Regulation / physiology*
  • Homeostasis / physiology*
  • Models, Biological
  • Phosphorylation
  • Protein Kinases / metabolism*
  • Repressor Proteins / metabolism
  • Signal Transduction / physiology*
  • Wnt Proteins / metabolism*
  • beta Catenin / metabolism*

Substances

  • Axin Protein
  • Repressor Proteins
  • Wnt Proteins
  • beta Catenin
  • Protein Kinases