Modulating T-cell homeostasis with IL-7: preclinical and clinical studies

J Intern Med. 2009 Aug;266(2):141-53. doi: 10.1111/j.1365-2796.2009.02085.x.


Interleukin-7 (IL-7) is required for the development and survival of T cells and plays a critical role in modulating T-cell homeostasis. This review will address current understanding of IL-7 biology, review recent clinical experiences and discuss potential future clinical applications of IL-7, or IL-7 blockade, in the setting of disease.

Publication types

  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Autoimmune Diseases / immunology
  • Autoimmune Diseases / therapy
  • HIV Infections / immunology
  • HIV Infections / therapy
  • Homeostasis / immunology
  • Humans
  • Immunotherapy / methods*
  • Interleukin-7 / immunology*
  • Neoplasms / immunology
  • Neoplasms / therapy
  • Randomized Controlled Trials as Topic
  • T-Lymphocytes / immunology*


  • Interleukin-7