Abstract
Benzyne-[2 + 2] cycloadditions with enamides are described. This effort led to the development of a highly stereoselective tandem [2 + 2] cycloaddition-pericyclic ring-opening-intramolecular-N-tethered-[4 + 2] cycloaddition for rapid assembly of nitrogen heterocycles.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Amides / chemistry
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Benzene Derivatives / chemistry*
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Combinatorial Chemistry Techniques
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Cyclization
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Heterocyclic Compounds / chemical synthesis*
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Heterocyclic Compounds / chemistry
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Molecular Structure
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Nitrogen / chemistry*
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Stereoisomerism
Substances
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Amides
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Benzene Derivatives
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Heterocyclic Compounds
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benzyne
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Nitrogen