Association analysis of serotonin receptor 1B (HTR1B) and brain-derived neurotrophic factor gene polymorphisms in Borderline personality disorder

J Neural Transm (Vienna). 2009 Sep;116(9):1185-8. doi: 10.1007/s00702-009-0264-3. Epub 2009 Jul 21.

Abstract

The purpose of this study was to test for association between Borderline personality disorder (BPD) and variants of the HTR1B and the brain-derived neurotrophic factor (BDNF) gene. We genotyped four HTR1B and the functional BDNF G196A marker in 161 Caucasian BPD patients and 156 healthy controls. There were no significant differences between groups in genotype or haplotype distribution of HTR1B markers or in genotype distribution of the BDNF marker. Logistic regression analyses revealed an over-representation of the BDNF 196A allele in HTR1B A-161 allele carrying BPD patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Borderline Personality Disorder / genetics*
  • Brain-Derived Neurotrophic Factor / genetics*
  • European Continental Ancestry Group
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease*
  • Genome-Wide Association Study
  • Genotype
  • Humans
  • Logistic Models
  • Male
  • Polymorphism, Single Nucleotide / genetics*
  • Receptor, Serotonin, 5-HT1B / genetics*

Substances

  • Brain-Derived Neurotrophic Factor
  • HTR1B protein, human
  • Receptor, Serotonin, 5-HT1B