Staging non-small cell carcinoma of the lung using technetium-99m-labeled monoclonal antibodies

Hematol Oncol Clin North Am. 1990 Dec;4(6):1069-78.


A technetium-labeled monoclonal antibody was administered to 52 patients with non-small cell lung carcinoma, either to stage the mediastinum preoperatively or to detect distant metastases. Results from planar and tomographic imaging are compared to CT and histologic confirmation. Differences in detection rates and predictive values between imaging modalities are discussed. The authors conclude that imaging with a technetium-labeled monoclonal antibody is safe and accurate and may be useful for staging patients with either operable or inoperable non-small cell lung cancer.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Multicenter Study

MeSH terms

  • Adult
  • Antibodies, Monoclonal*
  • Antibodies, Neoplasm*
  • Carcinoma, Non-Small-Cell Lung / diagnostic imaging*
  • Carcinoma, Non-Small-Cell Lung / pathology
  • Humans
  • Immunoglobulin Fab Fragments
  • Immunoglobulin G
  • Lung / diagnostic imaging
  • Lung Neoplasms / diagnostic imaging*
  • Lung Neoplasms / pathology
  • Mediastinum / diagnostic imaging
  • Neoplasm Metastasis / diagnostic imaging
  • Neoplasm Staging / methods*
  • Organ Specificity
  • Pilot Projects
  • Preoperative Care
  • Reagent Kits, Diagnostic
  • Technetium*
  • Tomography, Emission-Computed, Single-Photon*


  • Antibodies, Monoclonal
  • Antibodies, Neoplasm
  • Immunoglobulin Fab Fragments
  • Immunoglobulin G
  • Reagent Kits, Diagnostic
  • Technetium