Association of MMP1, MMP3, MMP9, and MMP12 polymorphisms with risk and clinical course of multiple sclerosis in a Polish population

Abstract

Single nucleotide polymorphisms in human MMP genes, including MMP1 (-1637 1G>2G), MMP3 (-1612 5A>6A), MMP9 (-1562 C>T), and MMP12 (-82 A>G), and their impact on multiple sclerosis risk and disease progression in a Polish population were investigated. Increased risk of MS was found among carriers of at least one T allele of MMP9 -1562 C>T (OR, 1.7; p=0.0030) and one G allele of MMP12 -82 A>G (OR, 3.9; p<0.00001). Additionally, an association between MMP9 genotype and MMP-9 levels in peripheral blood was detected. Our results suggest that MMP9 -1562 C>T and MMP12 -82 A>G polymorphisms affect susceptibility to multiple sclerosis.