Reactive oxygen species-dependent signaling regulates cancer

Cell Mol Life Sci. 2009 Dec;66(23):3663-73. doi: 10.1007/s00018-009-0099-y. Epub 2009 Jul 24.


Historically, it has been assumed that oxidative stress contributes to tumor initiation and progression solely by inducing genomic instability. Recent studies indicate that reactive oxygen species are upregulated in tumors and can lead to aberrant induction of signaling networks that cause tumorigenesis and metastasis. Here we review the role of redox-dependent signaling pathways and transcription factors that regulate tumorigenesis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Proliferation
  • DNA Damage
  • Genomic Instability
  • Humans
  • Mitochondrial Proteins / genetics
  • Models, Biological
  • Neoplasms / genetics
  • Neoplasms / metabolism
  • Oncogenes / physiology
  • Oxidation-Reduction
  • Reactive Oxygen Species / metabolism*
  • Signal Transduction*
  • Transcription Factors / physiology


  • Mitochondrial Proteins
  • Reactive Oxygen Species
  • Transcription Factors