Obstetric and perinatal outcome in HIV positive women receiving HAART in urban Nigeria

Arch Gynecol Obstet. 2010 Jun;281(6):991-4. doi: 10.1007/s00404-009-1186-x. Epub 2009 Jul 24.


Purpose: To compare the outcome of pregnancy between HIV positive pregnant women on highly active antiretroviral therapy (HAART) and HIV negative controls.

Methods: A prospective matched case-control study.

Results: HIV positive women were significantly more likely to have anaemia in pregnancy [p < 0.001, odds ratio (95% CI) 5.66 (3.0-10.5)], intrauterine growth restriction [p = 0.002, odds ratio (95%CI) 13.82 (1.8-106.7)], preterm labour [p = 0.03, odds ratio (95% CI) 2.89 (1.2-7.0)] and birth weight less than 2,500 g [p < 0.0001, odds ratio (95% CI) 5.43 (2.4-12.0)]. The 5-min apgar score less than 7, admission into neonatal unit, stillbirth and perinatal mortality were comparable between the two groups.

Conclusion: Anaemia in pregnancy, intrauterine growth restriction, preterm labour and birth weight less than 2,500 g are important complications among HIV positive pregnant women. This information is vital for strategic antenatal care planning to improve obstetric and perinatal outcome in these women.

MeSH terms

  • Adult
  • Anemia / etiology
  • Antiretroviral Therapy, Highly Active
  • Case-Control Studies
  • Female
  • Fetal Growth Retardation / etiology
  • HIV Infections / complications
  • HIV Infections / drug therapy*
  • Humans
  • Infant, Low Birth Weight
  • Infant, Newborn
  • Nigeria
  • Obstetric Labor, Premature / etiology
  • Pregnancy
  • Pregnancy Complications, Infectious / drug therapy*
  • Pregnancy Outcome
  • Prospective Studies
  • Urban Population
  • Young Adult