Antineuronal antibodies in sporadic late-onset cerebellar ataxia

J Neurol. 2010 Jan;257(1):59-62. doi: 10.1007/s00415-009-5262-8. Epub 2009 Jul 24.


Sporadic late-onset cerebellar ataxia of unknown cause is considered a neurodegenerative disorder whose underlying mechanisms are still unknown. To identify antineuronal autoantibodies, immunohistochemical and immunoblotting techniques were performed in 67 patients with sporadic cerebellar degeneration of unknown cause. Elevated P/Q-type voltage-gated calcium channel (VGCC)-specific antibodies were found in eight patients (11.9%). There was no hint of a paraneoplastic disorder in any of the patients. The present findings suggest an autoimmune contribution to the pathophysiology of a subgroup of sporadic late-onset cerebellar ataxia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age of Onset
  • Aged
  • Autoantibodies / blood*
  • Calcium Channels, P-Type / immunology*
  • Calcium Channels, Q-Type / immunology*
  • Cerebellar Ataxia / immunology*
  • Female
  • Humans
  • Immunoblotting
  • Immunohistochemistry
  • Male
  • Middle Aged
  • Neurons / immunology*
  • Paraneoplastic Cerebellar Degeneration


  • Autoantibodies
  • Calcium Channels, P-Type
  • Calcium Channels, Q-Type