In vitro UV-A protection factor (PF-UVA) of organic and inorganic sunscreens

Pharm Dev Technol. 2009;14(4):369-72. doi: 10.1080/10837450802683966.


The objective of this research was to evaluate the efficacy of various sunscreen agents incorporated into an O/W emulsion. Within the scope of this study only an in vitro method was used. According to selected filter UVA, we can obtain more or less effective creams. With the seven available filters, we can cover a range of values between 2 and 12. In addition to these seven filters absorbing in UVA range, variously coated titanium dioxide and zinc oxide were tested as well. So it appears that the best organic UVA filter is anisotriazine at 10% (PF-UVA = 11.82). Its effectiveness is comparable with that of the titanium dioxide forms used at 25%. Photostability in Suntest showed that the more photostable UVA-filters are the benzophenones.

Publication types

  • Comparative Study

MeSH terms

  • Drug Stability
  • Emulsions
  • Phenols / chemistry*
  • Sunlight
  • Sunscreening Agents / chemistry*
  • Titanium / chemistry
  • Triazines / chemistry*
  • Ultraviolet Rays*
  • Zinc Oxide / chemistry


  • Emulsions
  • Phenols
  • Sunscreening Agents
  • Triazines
  • titanium dioxide
  • Titanium
  • bis-ethylhexyloxyphenol methoxyphenyl triazine
  • Zinc Oxide