Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2008 Jan;1(1):56-67.
doi: 10.2174/1874473710801010056.

Alcohol Abuse, Immunosuppression, and Pulmonary Infection

Affiliations
Review

Alcohol Abuse, Immunosuppression, and Pulmonary Infection

Ping Zhang et al. Curr Drug Abuse Rev. .

Abstract

Excessive alcohol consumption predisposes the host to a wide range of infectious complications, particularly pulmonary infections. Factors that contribute to the development of pulmonary infections in alcohol-abusing patients include dysfunction of the protective barriers in the respiratory tract, aspiration of oropharyngeal contents, nutritional deficiencies, liver disease, and impairment of host defense mechanisms. This review discusses the complex host-pathogen interactions in the airways with an emphasis on how alcohol consumption adversely affects these mechanisms and predisposes the host to infections. Potential immunomodulatory strategies for enhancing host defense function in alcohol-consuming patients are also discussed.

Similar articles

See all similar articles

Cited by 38 articles

See all "Cited by" articles

Publication types

MeSH terms

Feedback