Wild rice ( Zizania latifolia (Griseb) Turcz) improves the serum lipid profile and antioxidant status of rats fed with a high fat/cholesterol diet

Br J Nutr. 2009 Dec;102(12):1723-7. doi: 10.1017/S0007114509991036.


The diet consumed by urban residents in modern China has become rich in saturated fats and cholesterol. In addition, the diet is high in carbohydrates from white rice and processed wheat starch. The aim of the present study was to determine the effects of replacing white rice and processed wheat starch with wild rice (WR) as the chief source of dietary carbohydrates. Rats fed with the diet patterned after the diet consumed by city residents of modern China showed elevated serum lipid levels comparable with rats consuming a high fat/cholesterol diet known to induce hyperlipidaemia in this species. Meanwhile, rats consuming the city diet with WR as the carbohydrate source suppressed the increase in serum TAG and total cholesterol, and the decrease in HDL cholesterol level. In addition, the rats fed the WR diet suppressed the build-up of oxidative stress by improving antioxidant capacity, increasing superoxide dismutase activity and reducing malondialdehyde concentration, both in the serum and liver. These findings illustrate that WR is effective in suppressing hyperlipidaemia and oxidative stress in rats even when the diet consumed is high in fat and cholesterol.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antioxidants / analysis*
  • Cholesterol, Dietary / administration & dosage*
  • Diet
  • Dietary Carbohydrates / administration & dosage*
  • Dietary Fats / administration & dosage*
  • Lipids / analysis
  • Lipids / blood*
  • Liver / chemistry
  • Liver / ultrastructure
  • Male
  • Malondialdehyde / blood
  • Organ Size
  • Oxidative Stress
  • Poaceae*
  • Rats
  • Rats, Sprague-Dawley
  • Superoxide Dismutase / blood


  • Antioxidants
  • Cholesterol, Dietary
  • Dietary Carbohydrates
  • Dietary Fats
  • Lipids
  • Malondialdehyde
  • Superoxide Dismutase