Abstract
Glycomonomers of sialic acid in which the acetamide group at C-5 was converted into two kinds of C=C double bond substituents were prepared and the fully protected glycomonomers were directly polymerized before deprotection steps. Radical polymerization with acrylamide in DMF in the presence of ammonium persulfate and N,N,N',N'-tetramethylethylenediamine proceeded smoothly and gave corresponding sialopolymers. Interestingly glycomonomers had hemagglutination inhibitory activities not only for H1N1 but also for H3N2 of human influenza virus strains.
MeSH terms
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / chemistry
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Antiviral Agents / pharmacology
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Hemagglutinin Glycoproteins, Influenza Virus / chemistry*
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Hemagglutinin Glycoproteins, Influenza Virus / metabolism
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Humans
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Influenza A virus / drug effects
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N-Acetylneuraminic Acid / analogs & derivatives*
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N-Acetylneuraminic Acid / chemical synthesis
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N-Acetylneuraminic Acid / pharmacology
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Polymers / chemical synthesis*
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Polymers / chemistry
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Polymers / pharmacology
Substances
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Antiviral Agents
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Hemagglutinin Glycoproteins, Influenza Virus
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Polymers
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N-Acetylneuraminic Acid