Formins and microtubules

Biochim Biophys Acta. 2010 Feb;1803(2):164-73. doi: 10.1016/j.bbamcr.2009.07.006. Epub 2009 Jul 23.

Abstract

Formins have recently been recognized as prominent regulators of the microtubule (MT) cytoskeleton where they modulate the dynamics of selected MTs in interphase and mitosis. The association of formins with the MT cytoskeleton and their action on MT dynamics are relatively unexplored areas, yet growing evidence supports a direct role in their regulation of MT stability independent of their activity on actin. Formins regulate MT stability alone or in combination with accessory MT binding proteins that have previously been implicated in the stabilization of MTs downstream of polarity cues. As actin and MT arrays are typically remodeled downstream of signaling pathways that orchestrate cell shape and division, formins are emerging as excellent candidates for coordinating the responses of the cytoskeletal in diverse regulated and homeostatic processes.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Division / physiology
  • Cytoskeleton / metabolism
  • Fetal Proteins / chemistry
  • Fetal Proteins / genetics
  • Fetal Proteins / metabolism*
  • Formins
  • Microfilament Proteins / chemistry
  • Microfilament Proteins / genetics
  • Microfilament Proteins / metabolism*
  • Microtubules / chemistry
  • Microtubules / genetics
  • Microtubules / metabolism*
  • Neurons / cytology
  • Neurons / metabolism
  • Nuclear Proteins / chemistry
  • Nuclear Proteins / genetics
  • Nuclear Proteins / metabolism*
  • Viruses / pathogenicity

Substances

  • Fetal Proteins
  • Formins
  • Microfilament Proteins
  • Nuclear Proteins