MRI guidance for accelerated partial breast irradiation in prone position: imaging protocol design and evaluation

Int J Radiat Oncol Biol Phys. 2009 Sep 1;75(1):285-93. doi: 10.1016/j.ijrobp.2009.03.063. Epub 2009 Jul 23.


Purpose: To design and evaluate a magnetic resonance imaging (MRI) protocol to be incorporated in the simulation process for external beam accelerated partial breast irradiation.

Methods and materials: An imaging protocol was developed based on an existing breast MRI technique with the patient in the prone position on a dedicated coil. Pulse sequences were customized to exploit T1 and T2 contrast mechanisms characteristic of lumpectomy cavities. A three-dimensional image warping algorithm was included to correct for geometric distortions related to nonlinearity of spatially encoding gradients. Respiratory motion, image distortions, and susceptibility artifacts of 3.5-mm titanium surgical clips were examined. Magnetic resonance images of volunteers were acquired repeatedly to analyze residual setup deviations resulting from breast tissue deformation.

Results: The customized sequences generated high-resolution magnetic resonance images emphasizing lumpectomy cavity morphology. Respiratory motion was negligible with the subject in the prone position. The gradient-induced nonlinearity was reduced to less than 1 mm in a region 15 cm away from the isocenter of the magnet. Signal-void regions of surgical clips were 4 mm and 8 mm for spin echo and gradient echo images, respectively. Typical residual repositioning errors resulting from breast deformation were estimated to be 3 mm or less.

Conclusions: MRI guidance for accelerated partial breast irradiation with the patient in the prone position with adequate contrast, spatial fidelity, and resolution is possible.

Publication types

  • Evaluation Study

MeSH terms

  • Algorithms
  • Artifacts
  • Breast Neoplasms / pathology*
  • Breast Neoplasms / radiotherapy*
  • Breast Neoplasms / surgery
  • Female
  • Humans
  • Magnetic Resonance Imaging / methods*
  • Magnetic Resonance Imaging, Interventional / methods
  • Mastectomy, Segmental*
  • Movement
  • Prone Position
  • Radiotherapy / methods
  • Reproducibility of Results
  • Respiration
  • Seroma / pathology*