How Human Pathogenic Fungi Sense and Adapt to pH: The Link to Virulence

Curr Opin Microbiol. 2009 Aug;12(4):365-70. doi: 10.1016/j.mib.2009.05.006. Epub 2009 Jul 23.

Abstract

The ability of fungal pathogens to cause disease is dependent on the ability to grow within the human host environment. In general, the human host environment can be considered a slightly alkaline environment, and the ability of fungi to grow at this pH is essential for pathogenesis. The Rim101 signal transduction pathway is the primary pH sensing pathway described in the pathogenic fungi, and in Candida albicans, it is required for a variety of diseases. As more detailed analyses have been conducted studying pathogenesis at the molecular level, it has become clear that the Rim101 pathway, and pH responses in general, play an intimate role in pathogenesis beyond simply allowing the organism to grow. Here, several recent advances into Rim101-dependent functions implicated in disease progression are discussed.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Candida albicans / pathogenicity*
  • Candida albicans / physiology*
  • Candidiasis / microbiology
  • DNA-Binding Proteins / physiology
  • Fungal Proteins / physiology
  • Humans
  • Hydrogen-Ion Concentration
  • Models, Biological
  • Stress, Physiological*
  • Virulence
  • Virulence Factors / physiology

Substances

  • DNA-Binding Proteins
  • Fungal Proteins
  • RIM101 protein, Candida albicans
  • Virulence Factors