RIP kinases at the crossroads of cell death and survival

Cell. 2009 Jul 23;138(2):229-32. doi: 10.1016/j.cell.2009.07.006.


Protein kinases of the receptor interacting protein (RIP) family collaborate with death receptor proteins to regulate cell death. Recent studies (Cho et al., 2009; He et al., 2009; Zhang et al., 2009) reveal that the RIP3 kinase functions with RIP1 at the crossroads of apoptosis, necroptosis, and cell survival.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review
  • Comment

MeSH terms

  • Animals
  • Cell Death*
  • Cell Survival*
  • Humans
  • Mice
  • Nuclear Pore Complex Proteins / metabolism
  • RNA-Binding Proteins / metabolism
  • Receptor-Interacting Protein Serine-Threonine Kinases / metabolism*
  • Signal Transduction


  • AGFG1 protein, human
  • Nuclear Pore Complex Proteins
  • RNA-Binding Proteins
  • RIPK3 protein, human
  • Receptor-Interacting Protein Serine-Threonine Kinases