E-cadherin and metalloproteinase-1 and -7 polymorphisms in colorectal cancer

Int J Biol Markers. Apr-Jun 2009;24(2):99-106.

Abstract

Purpose: E-cadherin (CDH1) and metalloproteinase (MMP) polymorphisms could play a crucial role in cancer invasion. Our aim was to investigate the influence of the -160C/A CDH1, -1607ins/delG MMP-1 and -181A/G MMP-7 polymorphisms on the frequency and progression of colorectal cancer (CRC).

Experimental design: A total of 130 patients with CRC and 130 noncancer controls were studied. The -160C/A CDH1, -1607ins/delG MMP-1 and -181A/G MMP-7 genotypes were analyzed by polymerase chain reaction-restriction fragment length polymorphism.

Results: Patients with the 1G allele and a family history of CRC showed a six times higher risk of developing CRC (OR: 6.45, 95% CI: 2.02-20.6, p=0.001). The A/A CDH1 genotype was associated with a higher risk of metastatic disease (OR: 3.43, 95% CI: 1.27-9.27, p=0.023). A higher marginal risk of metastatic disease was observed for MMP-1 genotypes 1G/1G and 1G/2G (OR: 2.97, 95% CI: 0.93-9.47, p=0.098).

Conclusions: The -160C/A CDH1, -1607ins/delG MMP-1 and -181A/G MMP-7 single nucleotide polymorphisms did not modify the risk of CRC development. Patients with the 1G/1G or 1G/2G genotype and a family history of CRC presented a higher risk of CRC. The AA CDH1 and 1G/1G and 1G/2G MMP-1 genotypes might be associated with advanced metastatic disease, but are not markers of lymphatic metastasis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Cadherins / genetics*
  • Cadherins / metabolism
  • Colorectal Neoplasms / genetics*
  • Female
  • Humans
  • Lymphatic Metastasis
  • Male
  • Matrix Metalloproteinase 1 / genetics*
  • Matrix Metalloproteinase 7 / genetics*
  • Middle Aged
  • Neoplasm Metastasis
  • Polymorphism, Genetic
  • Risk

Substances

  • Cadherins
  • Matrix Metalloproteinase 7
  • Matrix Metalloproteinase 1