Lambert-Eaton myasthenic syndrome revealing an abdominal neuroblastoma

J Pediatr Surg. 2009 Aug;44(8):E5-7. doi: 10.1016/j.jpedsurg.2009.04.023.


Lambert-Eaton myasthenic syndrome is a paraneoplastic syndrome that may reveal a primitive tumor. Neuroblastoma in children and small cell lung carcinoma in adults are the leading tumors revealed or expressed by paraneoplastic phenomena. The clinical neurologic manifestations of Lambert-Eaton myasthenic syndrome are muscular weakness, sleepiness, absence of reflexes, and dysautonomia. Neurologic manifestations are explained by the induction of an autoimmune response because of the presence of antigens that are expressed by the tumor. Neurologic paraneoplastic disorders may also be the result of toxicity of drugs, coagulopathy, infection, or metabolic diseases. We describe the case of a 13-month-old child with unusual neurologic symptoms because of the presence of an abdominal neuroblastoma.

Publication types

  • Case Reports

MeSH terms

  • Abdominal Neoplasms / diagnosis*
  • Abdominal Neoplasms / surgery
  • Diagnosis, Differential
  • Diagnostic Imaging
  • Female
  • Humans
  • Infant
  • Lambert-Eaton Myasthenic Syndrome / diagnosis*
  • Lambert-Eaton Myasthenic Syndrome / surgery
  • Neuroblastoma / diagnosis*
  • Neuroblastoma / surgery