Clinical analyses and short-term prognoses of neonates with subependymal cysts

Pediatr Neurol. 1990 Nov-Dec;6(6):375-8. doi: 10.1016/0887-8994(90)90003-j.


Twenty-one neonates with subependymal cysts detected by neurosonography soon after birth were prospectively examined. The clinical and cranial sonographic findings were evaluated with respect to short-term prognosis. The prognosis was poor in 6 patients with congenital viral infection (4 with cytomegalovirus infection and 2 with rubella infection). Five patients also had neurodevelopmental abnormalities (2 with neonatal epileptic seizures, 2 with chromosomal abnormalities, and 1 with lissencephaly). The remaining 10 patients had normal psychomotor development. The incidence of congenital viral infection was statistically correlated with a poor neurodevelopmental outcome. A correlation did not exist between the short-term prognosis and each of the other clinical factors or cranial sonographic findings. Our evidence suggests that further investigation of possible subependymal cyst etiologies is required during a careful, long-term follow-up period.

MeSH terms

  • Brain Diseases / congenital*
  • Brain Diseases / diagnostic imaging
  • Cysts / congenital*
  • Cysts / diagnostic imaging
  • Cytomegalovirus Infections / congenital*
  • Cytomegalovirus Infections / diagnostic imaging
  • Echoencephalography
  • Ependyma / abnormalities*
  • Ependyma / diagnostic imaging
  • Female
  • Follow-Up Studies
  • Humans
  • Infant, Newborn
  • Infant, Premature, Diseases / diagnostic imaging*
  • Male
  • Risk Factors
  • Rubella Syndrome, Congenital / diagnostic imaging*