1H, 13C, and 15N resonance assignments of FK506-binding domain of Plasmodium falciparum FKBP35

Cong Bao Kang; Hong Ye; Hye Rim Yoon; Ho Sup Yoon

doi:10.1007/s12104-007-9005-4

1H, 13C, and 15N resonance assignments of FK506-binding domain of Plasmodium falciparum FKBP35

Biomol NMR Assign. 2007 Jul;1(1):27-8. doi: 10.1007/s12104-007-9005-4. Epub 2007 May 5.

Authors

Cong Bao Kang¹, Hong Ye, Hye Rim Yoon, Ho Sup Yoon

Affiliation

¹ School of Biological Science, Nanyang Technological University, 60 Nanyang Drive, Singapore 637665, Singapore.

PMID: 19636818
DOI: 10.1007/s12104-007-9005-4

Abstract

The immunosuppressant FK506 binds Plasmodium falciparum FK-506 binding protein 35 (PfFKBP35) and shows anti-malarial activity. To understand molecular mechanism of the drug on the parasite, we have done NMR studies. Here, we report the assignment of FK506-binding domain of PfFKBP35.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Binding Sites
Nuclear Magnetic Resonance, Biomolecular
Plasmodium falciparum / chemistry*
Plasmodium falciparum / genetics
Protein Structure, Tertiary
Protozoan Proteins / chemistry*
Protozoan Proteins / genetics
Recombinant Proteins / chemistry
Recombinant Proteins / genetics
Tacrolimus Binding Proteins / chemistry*
Tacrolimus Binding Proteins / genetics

Substances

Protozoan Proteins
Recombinant Proteins
Tacrolimus Binding Proteins