Sulindac inhibits canonical Wnt signaling by blocking the PDZ domain of the protein Dishevelled

Angew Chem Int Ed Engl. 2009;48(35):6448-52. doi: 10.1002/anie.200902981.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptor Proteins, Signal Transducing / chemistry
  • Adaptor Proteins, Signal Transducing / metabolism*
  • Animals
  • Antineoplastic Agents / pharmacology*
  • Dishevelled Proteins
  • Humans
  • Models, Molecular
  • Nuclear Proteins / metabolism
  • PDZ Domains
  • Phosphoproteins / chemistry
  • Phosphoproteins / metabolism*
  • Protein Binding
  • Signal Transduction / drug effects*
  • Sulindac / pharmacology*
  • Wnt Proteins / metabolism*
  • Xenopus / embryology
  • Xenopus / metabolism

Substances

  • Adaptor Proteins, Signal Transducing
  • Antineoplastic Agents
  • Dishevelled Proteins
  • Nuclear Proteins
  • Phosphoproteins
  • Wnt Proteins
  • nuclear protein B4, Xenopus laevis
  • Sulindac