Synthesis of tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate

Org Lett. 2009 Aug 20;11(16):3523-5. doi: 10.1021/ol901325s.


Two efficient and scaleable synthetic routes to previously unknown bifunctional tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate are described. This compound and related intermediates described herein are useful for further selective derivation on the azetidine and cyclobutane rings providing a convenient entry point to novel compounds accessing chemical space complementary to piperidine ring systems.

MeSH terms

  • Aza Compounds / chemical synthesis*
  • Aza Compounds / chemistry*
  • Molecular Structure
  • Piperidines / chemistry*
  • Spiro Compounds / chemical synthesis*
  • Spiro Compounds / chemistry*
  • Stereoisomerism


  • Aza Compounds
  • Piperidines
  • Spiro Compounds
  • tert-butyl 6-oxo-2-azaspiro(3.3)heptane-2-carboxylate
  • piperidine