A new triglucosylated naphthalene glycoside from Aloe vera L

Fitoterapia. 2010 Jan;81(1):59-62. doi: 10.1016/j.fitote.2009.07.006. Epub 2009 Jul 26.

Abstract

A new triglucosylated naphthalene derivative, named aloveroside A (1), together with two known anthraquinone dimers and two 6-phenyl-2-pyrone derivatives, was isolated from the Aloe vera ethanolic extracts. The structure of 1 was established as 1-(((4-(1-O-beta-D-glucopyranosyl -(1-->4)-beta-D-xylopyranoside)-hydroxymethyl)-1-hydroxy-8-O-alpha-L-rhamnopyranoside)naphthalene-2-yl)-ethanone by means of spectroscopic evidences and chemical methods. All these compounds were tested for their BACE inhibitory activity but no significant activities were found.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aloe / chemistry*
  • Amyloid Precursor Protein Secretases / antagonists & inhibitors
  • Drug Evaluation, Preclinical
  • Glycosides / chemistry
  • Glycosides / isolation & purification*
  • Glycosides / pharmacology
  • Molecular Structure
  • Naphthalenes / chemistry
  • Naphthalenes / isolation & purification*
  • Naphthalenes / pharmacology
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology

Substances

  • Glycosides
  • Naphthalenes
  • Plant Extracts
  • aloveroside A
  • Amyloid Precursor Protein Secretases