Regulatory roles of natural antisense transcripts

Nat Rev Mol Cell Biol. 2009 Sep;10(9):637-43. doi: 10.1038/nrm2738. Epub 2009 Jul 29.


Mammalian genomes encode numerous natural antisense transcripts, but the function of these transcripts is not well understood. Functional validation studies indicate that antisense transcripts are not a uniform group of regulatory RNAs but instead belong to multiple categories with some common features. Recent evidence indicates that antisense transcripts are frequently functional and use diverse transcriptional and post-transcriptional gene regulatory mechanisms to carry out a wide variety of biological roles.

Publication types

  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation / physiology*
  • Humans
  • RNA, Antisense / physiology*


  • RNA, Antisense