Identification of a crenarchaeal orthologue of Elf1: implications for chromatin and transcription in Archaea

Biol Direct. 2009 Jul 29;4:24. doi: 10.1186/1745-6150-4-24.

Abstract

The transcription machineries of Archaea and eukaryotes are similar in many aspects, but little is understood about archaeal chromatin and its role in transcription. Here, we describe the identification in hyperthermophilic Crenarchaeota and a Korarchaeon of an orthologue of the eukaryotic transcription elongation factor Elf1, which has been shown to function in chromatin structure maintenance of actively transcribed templates. Our discovery has implications for the relationship of chromatin and transcription in Archaea and the evolution of these processes in eukaryotes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Archaea / genetics*
  • Archaeal Proteins / genetics*
  • Archaeal Proteins / metabolism*
  • Chromatin / genetics*
  • Crenarchaeota / genetics*
  • Evolution, Molecular
  • Gene Expression Regulation, Archaeal* / genetics
  • Transcription Factors / genetics*

Substances

  • Archaeal Proteins
  • Chromatin
  • Transcription Factors