Abstract
Central 5-HT2 and 5-HT1C receptors appear to be relatively resistant to up-regulation. 5-HT2 receptors are not upregulated after denervation of 5-HT neurons and chronic administration of antagonists elicits a paradoxical downregulation of both receptors. This article explores the possible explanations for these anomalous findings.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Adaptation, Physiological / physiology
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Animals
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Brain / metabolism*
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Down-Regulation / physiology
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Humans
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Hydrolysis
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Phosphatidylinositols / metabolism*
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Receptors, Serotonin / physiology*
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Up-Regulation / physiology
Substances
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Phosphatidylinositols
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Receptors, Serotonin