Adaptive regulation of central serotonin receptors linked to phosphoinositide hydrolysis

Neuropsychopharmacology. 1990 Oct-Dec;3(5-6):411-6.

Abstract

Central 5-HT2 and 5-HT1C receptors appear to be relatively resistant to up-regulation. 5-HT2 receptors are not upregulated after denervation of 5-HT neurons and chronic administration of antagonists elicits a paradoxical downregulation of both receptors. This article explores the possible explanations for these anomalous findings.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adaptation, Physiological / physiology
  • Animals
  • Brain / metabolism*
  • Down-Regulation / physiology
  • Humans
  • Hydrolysis
  • Phosphatidylinositols / metabolism*
  • Receptors, Serotonin / physiology*
  • Up-Regulation / physiology

Substances

  • Phosphatidylinositols
  • Receptors, Serotonin