Dendritic signalling and homeostatic adaptation

Curr Opin Neurobiol. 2009 Jun;19(3):327-35. doi: 10.1016/j.conb.2009.07.002. Epub 2009 Jul 27.


Homeostatic plasticity mechanisms are employed by neurons to alter membrane excitability and synaptic strength to adapt to changes in network activity. Recent studies suggest that homeostatic processes can occur not only on a global scale but also within specific neuronal subcompartments, involving a wide range of molecules and signalling pathways. Here, we review new findings into homeostatic adaptation within dendrites and discuss potential signalling components and mechanisms that may mediate this local form of regulation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Calcium / physiology
  • Dendrites / physiology*
  • Homeostasis / physiology*
  • Models, Neurological
  • Neuronal Plasticity / physiology
  • Neurons / physiology
  • Synapses / physiology
  • Synaptic Transmission / physiology*


  • Calcium