Exploration of homodimer receptor: homodimer protein interactions

Int J Bioinform Res Appl. 2009;5(4):447-57. doi: 10.1504/IJBRA.2009.027518.


Homodimerisation is producing a protein?protein complex composed of two identical molecules. Dimerisation is a phenomenon often occurring in the regulation of biochemical systems like signal transduction pathways. We investigated whether the existence of a homodimer-activated receptor and the activation of homodimer transducers correspond to a more general pattern in cell signalling. We developed a workflow to merge data from the Gene Ontology and the BIND database to produce a list of interactions between homodimer receptors and homodimer proteins. Finally, we found a prevalence of homodimer-homodimer interactions in signalling systems in human cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Binding Sites
  • Computational Biology / methods*
  • Dimerization
  • Humans
  • Protein Multimerization
  • Proteins / chemistry*
  • Proteins / metabolism*


  • Proteins