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Review
. 2009 Oct;83(19):9618-29.
doi: 10.1128/JVI.01098-09. Epub 2009 Jul 29.

Virus-encoded Homologs of Cellular interleukin-10 and Their Control of Host Immune Function

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Free PMC article
Review

Virus-encoded Homologs of Cellular interleukin-10 and Their Control of Host Immune Function

Barry Slobedman et al. J Virol. .
Free PMC article

Figures

FIG. 1.
FIG. 1.
Structure of hIL-10 and vIL-10 homologs bound to the hIL-10R. hIL-10 (A), ebvIL-10 (B), and cmvIL-10 (C) dimers bound to soluble IL-10R1 (sIL-10R1) are shown. The interdomain angles of each IL-10 are shown at the top of each complex. The rotation (in degrees) of each IL-10 domain angle on the surface of sIL-10R1 is denoted by arrows where the movement is from the circle to the arrowhead. For the cmvIL-10/sIL-10R1 complex, the rotation of each sIL-10R1 relative to the hIL-10/sIL-10R1 complex is also shown.
FIG. 2.
FIG. 2.
Alignment of cellular and vIL-10 proteins. Proteins were aligned by the ClustalW method, using the MegAlign software program (Lasergene, DNASTAR). Cellular and vIL-10 host names are shown in italic and bold fonts, respectively. Nucleotide sequence accession numbers for the indicated genera or viruses are as follows: Ovis (sheep; GenBank accession number NP_001009327), Capra (goat; ABI20513), Bos (bovine; NP_776513), ORFV (AAC57332), equine herpesvirus 2 ([EHV2] AAB26148), Equus (horse; NP_001075959), Papio (baboon; Q5Q0V6), Macaca (rhesus macaque [Macaca mulatta]; NP_001038192), Homo sapiens (human; P22301), macacine herpesvirus 4 [McHV4]/rhesus lymphocryptovirus (AAK95412), EBV/human herpesvirus 4 (P03180), OvHV2 (ABB22222), LSDV (AAN02729), SPPV (NP_659579), GPV (GPV Pellor; YP_001293197), McHV3/RhCMV (AAF59907), African green monkey CMV ([AGMCMV] AAF63435), baboon CMV ([BaCMV] AAF63436), HCMV/human herpesvirus 5 (AAF36285), Cyprinus (common carp [Cyprinus carpio]; BAC76885), cyprinid herpesvirus 3 ([CyHV3] YP_001096169).

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