Efficacy of Silver Diamine Fluoride for Arresting Caries Treatment

J Dent Res. 2009 Jul;88(7):644-7. doi: 10.1177/0022034509338671.

Abstract

Arresting Caries Treatment (ACT) has been proposed to manage untreated dental caries in children. This prospective randomized clinical trial investigated the caries-arresting effectiveness of a single spot application of: (1) 38% silver diamine fluoride (SDF) with tannic acid as a reducing agent; (2) 38% SDF alone; (3) 12% SDF alone; and (4) no SDF application in primary teeth of 976 Nepalese schoolchildren. The a priori null hypothesis was that the different treatments have no effect in arresting active cavitated caries. Only the single application of 38% SDF with or without tannic acid was effective in arresting caries after 6 months (4.5 and 4.2 mean number of arrested surfaces; p < 0.001), after 1 year (4.1 and 3.4; p < 0.001), and after 2 years (2.2 and 2.1; p < 0.01). Tannic acid conferred no additional benefit. ACT with 38% SDF provides an alternative when restorative treatment for primary teeth is not an option.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cariostatic Agents / administration & dosage
  • Cariostatic Agents / therapeutic use*
  • Child
  • Child, Preschool
  • DMF Index
  • Dental Caries / drug therapy*
  • Dose-Response Relationship, Drug
  • Drug Combinations
  • Female
  • Fluorides, Topical / administration & dosage
  • Fluorides, Topical / therapeutic use*
  • Humans
  • Male
  • Prospective Studies
  • Quaternary Ammonium Compounds / administration & dosage
  • Quaternary Ammonium Compounds / therapeutic use*
  • Silver Compounds
  • Tannins / therapeutic use
  • Tooth, Deciduous

Substances

  • Cariostatic Agents
  • Drug Combinations
  • Fluorides, Topical
  • Quaternary Ammonium Compounds
  • Silver Compounds
  • Tannins
  • silver diamine fluoride