Retinoblastoma: the challenges of management in Ibadan, Nigeria

J Pediatr Hematol Oncol. 2009 Aug;31(8):552-5. doi: 10.1097/MPH.0b013e31819c5275.

Abstract

Background: Retinoblastoma is a common highly malignant tumor of the eye. Late presentation leads to poor survival rate in many developing countries.

Objective: To identify problems associated with management of retinoblastoma.

Methods: A retrospective review of cases of retinoblastoma at the University College Hospital, Ibadan, between January 1992 and December 2007.

Results: A total of 32 eyes of 26 patients were studied. Sixteen were males and 10 were females. Minimum age at presentation was 4 months and maximum age was 60 months (mean 30.69+/-14.2 mo). Over 90% presented after 1 month of onset. Reasons for late diagnosis included late presentation for unknown reasons, missed diagnosis, and mismanagement in a previous hospital. Eleven of 26 patients defaulted to avoid removal of the eye, and treatment was only completed in 5 patients. Problems included financial constraint regarding investigations and procurement of drugs, as well as availability of the chemotherapy.

Conclusions: Retinoblastoma is a problematic malignancy of childhood associated with management problems often related to difficulty with patients accepting removal of the affected eye and financial constraint for treatment.

MeSH terms

  • Age of Onset
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Male
  • Nigeria / epidemiology
  • Retinoblastoma / economics
  • Retinoblastoma / epidemiology
  • Retinoblastoma / surgery*
  • Retrospective Studies