Recent progress in the biology and physiology of sirtuins

Nature. 2009 Jul 30;460(7255):587-91. doi: 10.1038/nature08197.


The sirtuins are a highly conserved family of NAD(+)-dependent enzymes that regulate lifespan in lower organisms. Recently, the mammalian sirtuins have been connected to an ever widening circle of activities that encompass cellular stress resistance, genomic stability, tumorigenesis and energy metabolism. Here we review the recent progress in sirtuin biology, the role these proteins have in various age-related diseases and the tantalizing notion that the activity of this family of enzymes somehow regulates how long we live.

Publication types

  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aging / physiology
  • Animals
  • DNA Repair / physiology
  • Gene Expression Regulation, Enzymologic
  • Humans
  • Longevity / physiology
  • Sirtuins / metabolism
  • Sirtuins / physiology*
  • Stress, Physiological / physiology


  • Sirtuins