Age-related cognitive decline and nesting behavior in an APPswe/PS1 bigenic model of Alzheimer's disease

Brain Res. 2009 Oct 6;1292:93-9. doi: 10.1016/j.brainres.2009.07.066. Epub 2009 Jul 28.


A large series of 3-, 6-, 9-, and 12-month-old bigenic mice (N=240) with Swedish APP and A246E PS1 mutations was investigated in nest-building, spontaneous alternation, and two learning tasks. Progressive cognitive impairment was observed in APPswe/PS1 mice relative to controls for nest-building, spontaneous alternation, the reversal phase of left-right discrimination learning in a water-filled T-maze, and in retention of passive avoidance learning. The behavioral deficits in transgenic mice start at 6 months, appearing to offer an opportunity for assessing potential therapeutic agents in attenuating or preventing Alzheimer's disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging*
  • Alzheimer Disease / psychology*
  • Amyloid beta-Protein Precursor / genetics
  • Animals
  • Avoidance Learning
  • Cognition Disorders*
  • Discrimination Learning
  • Disease Models, Animal
  • Humans
  • Learning Disabilities*
  • Male
  • Maze Learning
  • Mice
  • Mice, Transgenic
  • Mutation
  • Nesting Behavior*
  • Neuropsychological Tests
  • Presenilin-1 / genetics
  • Protease Nexins
  • Receptors, Cell Surface / genetics
  • Time Factors


  • APP protein, human
  • Amyloid beta-Protein Precursor
  • Presenilin-1
  • Protease Nexins
  • Receptors, Cell Surface