Amphotropic murine leukemia retrovirus is not an acute pathogen for primates

Hum Gene Ther. Spring 1990;1(1):15-30. doi: 10.1089/hum.1990.1.1-15.

Abstract

The in vivo fate of amphotropic murine leukemia retrovirus was studied in five rhesus monkeys. Retrovirus infused intravenously into 3 normal animals and 1 immunosuppressed animal was cleared rapidly from the circulation and subsequent viremia has not been detected (mean follow-up of 27.4 months). A fifth monkey was immunosuppressed and transplanted with virus-producing autologous fibroblasts in addition to an intraperitoneal injection of virus. This animal was viremic for 2 days and its lymph node cells and peripheral blood mononuclear cells were shown to be producing virus for up to 22 days post-inoculation, but subsequently has been negative after 17.0 months of analysis. In the 5 animals studied (combined mean follow-up of 25.7 months), clinical illness has not been identified at any time. Therefore, murine amphotropic retroviruses do not appear to pose an acute health risk.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • AIDS-Related Complex / microbiology
  • Animals
  • Antigens, Viral / blood
  • Base Sequence
  • Blotting, Western
  • Fibroblasts / microbiology
  • Fibroblasts / transplantation
  • Immunosuppression
  • Injections, Intravenous
  • Leukemia Virus, Murine / genetics
  • Leukemia Virus, Murine / immunology
  • Leukemia Virus, Murine / pathogenicity*
  • Macaca mulatta
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • Precipitin Tests
  • Virus Replication

Substances

  • Antigens, Viral