Cellular angiofibroma of oral mucosa: report of two cases

Head Neck Pathol. 2009 Jun;3(2):136-9. doi: 10.1007/s12105-009-0112-7. Epub 2009 May 31.


Cellular angiofibroma is a benign vascular neoplasm that typically arises in the vulva, perineal, and paratesticular region. Microscopically the lesions exhibit multiple small, non-dilated capillary channels, many of which contain erythrocytes. The endothelial lining cells are prominent, with monomorphic oval nuclei. Interposed among the vessels are both delicate and mature collagen fibers with fibroblastic hypercellularity that is variable in older lesions where sclerosis is prominent. The lesions usually do not recur following simple excision. Recent evidence indicates that cellular angiofibromas may be cytogenetically related to spindle cell lipoma. This represents the first reported instances of cellular angiofibroma in the oral cavity.

Keywords: Angiofibroma; Hemangioma; Mesenchymal tumor; Oral cavity; Vascular tumor.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Angiofibroma / pathology*
  • Angiofibroma / surgery
  • Female
  • Humans
  • Mouth Mucosa / pathology*
  • Mouth Neoplasms / pathology*
  • Mouth Neoplasms / surgery