Ameliorative effects of ginger extract on paraben-induced lipid peroxidation in the liver of mice

Acta Pol Pharm. May-Jun 2009;66(3):225-8.

Abstract

We have evaluated the ameliorative effect of ginger extract on paraben (p-hydroxybenzoic acid)-induced lipid peroxidation in the liver of mice. Adult female albino mice were orally administered with 2.25 or 4.50 mg of paraben in 0.2 mL olive/animal/day (67.5 and 135 mg/kg of body weight) for 30 days. The results revealed significantly higher (p < or = 0.05) lipid peroxidation in the liver of paraben-treated mice than that of controls. As compared with the controls, the levels of non-enzymatic antioxidants: glutathione and ascorbic acid, as well as the enzymatic antioxidants: superoxide dismutase, glutathione peroxidase and catalase were significantly (p < or = 0.05) lowered in the liver of paraben-treated mice. Oral administration of aqueous extract of Zinziber officinale (3 mg/animal/day) along with paraben for 30 days (Groups 6 and 7) caused significant (p < or = 0.05) amelioration in paraben-induced lipid peroxidation and increased significantly (p < or = 0.05) the activities of enzymatic (superoxide dismutase, glutathione peroxidase, catalase) and contents of non-enzymatic (glutathione and ascorbic acid) antioxidants in the liver of mice, as compared with those given paraben alone (Groups 4, 5). Thus, oral administration of aqueous extract of Zinziber officinale along with paraben significantly (p < or = 0.05) ameliorates paraben-induced lipid peroxidation in the liver of mice.

MeSH terms

  • Administration, Oral
  • Animals
  • Antioxidants / metabolism
  • Ascorbic Acid / metabolism
  • Catalase / metabolism
  • Dose-Response Relationship, Drug
  • Female
  • Ginger / chemistry*
  • Glutathione / metabolism
  • Glutathione Peroxidase / metabolism
  • Lipid Peroxidation / drug effects*
  • Liver / drug effects*
  • Liver / metabolism
  • Mice
  • Mice, Inbred Strains
  • Parabens / administration & dosage
  • Parabens / toxicity
  • Plant Extracts / pharmacology*
  • Superoxide Dismutase / metabolism

Substances

  • Antioxidants
  • Parabens
  • Plant Extracts
  • Catalase
  • Glutathione Peroxidase
  • Superoxide Dismutase
  • Glutathione
  • Ascorbic Acid