Mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) in carcinogenesis

Cancer Lett. 2010 Mar 1;289(1):11-22. doi: 10.1016/j.canlet.2009.06.036. Epub 2009 Jul 30.


The cation-independent mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) is a multifunctional receptor. It is involved in a variety of cellular processes which become dysregulated in cancer. Its tumor suppressor role was recognized a long time ago. However, due to its multifunctionality, it is not easy to understand the extent of its relevance to normal cellular physiology. Accordingly, it is even more difficult understanding its role in carcinogenesis. This review presents critical and focused highlights of data relating to M6P/IGF2R, obtained during more than 25 years of cancer research.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Genes, Tumor Suppressor*
  • Genetic Predisposition to Disease
  • Humans
  • Insulin-Like Growth Factor II / genetics*
  • Insulin-Like Growth Factor II / metabolism*
  • Molecular Sequence Data
  • Mutation
  • Neoplasms / physiopathology*
  • Receptor, IGF Type 2 / genetics*
  • Receptor, IGF Type 2 / metabolism*


  • Receptor, IGF Type 2
  • Insulin-Like Growth Factor II