This article summarizes physiologic obstacles to exercise and reviews exercise interventions in fibromyalgia (FM). In addition, the authors describe the top 10 principles for successfully prescribing exercise in the comprehensive treatment of FM and provide a practical exercise resource table to share with patients. A therapeutic alliance between the provider and patient is enhanced if both understand the risks and benefits of exercise. Such an alliance increases the likelihood of the patient successfully integrating life-long exercise into his or her comprehensive FM treatment plan.