Raf-1 and squamous cell carcinoma: Rok-ing the boat

Cancer Cell. 2009 Aug 4;16(2):85-6. doi: 10.1016/j.ccr.2009.07.012.

Abstract

Squamous cell carcinoma (SCC) is the second most common form of nonmelanoma skin cancer. In this issue of Cancer Cell, Ehrenreiter et al. unveil a critical role for the Raf-1/Rok-alpha interaction in the pathogenesis of SCCs, thus paving the way for the development of therapeutic modalities to treat this malignancy.

Publication types

  • Comment

MeSH terms

  • Animals
  • Carcinoma, Squamous Cell / enzymology*
  • Carcinoma, Squamous Cell / genetics
  • Carcinoma, Squamous Cell / pathology
  • Cell Differentiation
  • Cell Proliferation
  • Keratinocytes / enzymology
  • Keratinocytes / pathology
  • Mice
  • Proto-Oncogene Proteins c-raf / genetics
  • Proto-Oncogene Proteins c-raf / metabolism
  • Proto-Oncogene Proteins c-raf / physiology*
  • Signal Transduction
  • Skin Neoplasms / enzymology*
  • Skin Neoplasms / genetics
  • Skin Neoplasms / pathology
  • rho-Associated Kinases / metabolism*

Substances

  • Proto-Oncogene Proteins c-raf
  • Rock2 protein, mouse
  • rho-Associated Kinases