Measuring the benefits of treatment for psychosis: validity and responsiveness of the EQ-5D

Br J Psychiatry. 2009 Aug;195(2):170-7. doi: 10.1192/bjp.bp.108.057380.

Abstract

Background: The UK National Institute for Health and Clinical Excellence (NICE) has recommended that cost-effectiveness analysis includes the EQ-5D; however, this is often not implemented in the area of mental health.

Aims: To assess the appropriateness of using the EQ-5D to measure improvements in mental health.

Method: Seventy-seven participants with psychosis were rated according to the EQ-5D and seven measures of mental health at both pre- and post-intervention. To assess construct validity we compared the (pre-intervention) mean EQ-5D scores for those with milder and more severe scores, according to each of the seven measures. To assess responsiveness we estimated the mean EQ-5D change score for those who improved (post-intervention), according to each of the measures.

Results: The mean EQ-5D score was more favourable for both those with milder scores (mean difference: 0.044 to 0.301) and for those who improved post-intervention (mean change: 0.029 to 0.117).

Conclusions: This suggests the EQ-5D should be considered for use in future cost-effectiveness studies in the area of mental health.

Publication types

  • Research Support, Non-U.S. Gov't
  • Validation Study

MeSH terms

  • Adolescent
  • Adult
  • Cognitive Behavioral Therapy / economics
  • Cost-Benefit Analysis
  • Female
  • Humans
  • Male
  • Mental Disorders / therapy*
  • Mental Health Services / economics*
  • Middle Aged
  • Outcome Assessment, Health Care / economics*
  • Quality of Life*
  • Surveys and Questionnaires / standards*
  • United Kingdom
  • Young Adult