Primary myelodysplastic syndrome in Jordan: a single-centre experience

Med Princ Pract. 2009;18(5):351-5. doi: 10.1159/000226286. Epub 2009 Jul 31.

Abstract

Objective: Study of the disease patterns and clinical evaluation of myelodysplastic syndrome (MDS).

Subjects and methods: A retrospective analysis was carried out on 85 patients, with MDS who were followed up over a period of 23 years at Jordan University Hospital, Amman, Jordan. Cases were analyzed according to the French, American and British Classification.

Results: Of the 85 patients, 42 (49.4%) were females and 43 (50%) males; mean age was 59 +/- 19 years (range 18-88). Most subtypes found in patients were refractory anemia (RA) in 27 (31.8%) and RA with excess blasts (RAEB) in 28 (32.9%). Adverse prognostic indicators were RAEB subtype and requirement for blood transfusion.

Conclusion: Our findings showed that MDSs appeared at a younger age and tended to be of the aggressive subtype. Chronic myelomonocytic leukemia subtype seemed to appear dominantly in men.

MeSH terms

  • Adolescent
  • Adult
  • Age Distribution
  • Aged
  • Aged, 80 and over
  • Anemia, Refractory, with Excess of Blasts / epidemiology
  • Anemia, Refractory, with Excess of Blasts / physiopathology*
  • Anemia, Sideroblastic / epidemiology
  • Anemia, Sideroblastic / physiopathology*
  • Developing Countries
  • Disease Progression
  • Female
  • Hospitals, University
  • Humans
  • Jordan / epidemiology
  • Kaplan-Meier Estimate
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / epidemiology
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / physiopathology*
  • Male
  • Middle Aged
  • Retrospective Studies
  • Sex Distribution
  • Young Adult