Histone macroH2A isoforms predict the risk of lung cancer recurrence

Oncogene. 2009 Sep 24;28(38):3423-8. doi: 10.1038/onc.2009.26. Epub 2009 Aug 3.


Lung cancer is the leading cause of cancer deaths. Despite optimal diagnosis and early treatment, many patients die of recurrent disease. There are no sufficiently useful biomarkers to predict the risk of tumor recurrence. Here, we show that expression of histone macroH2A1.1 and macroH2A2 predicts lung cancer recurrence, identifying these histone variants as a novel tool for an improved risk stratification of cancer patients. Moreover, macroH2A isoforms are highly expressed in cells undergoing senescence, a known antitumor mechanism, suggesting macroH2A1.1 may be a useful biomarker for senescent cells in tumors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Cycle
  • Cell Proliferation
  • Cellular Senescence
  • Gene Expression Regulation
  • Histones / analysis
  • Histones / genetics
  • Histones / physiology*
  • Humans
  • Lung Neoplasms / etiology*
  • Lung Neoplasms / pathology
  • Neoplasm Recurrence, Local / etiology*
  • Neoplasm Recurrence, Local / pathology
  • Protein Isoforms
  • Risk


  • Histones
  • Protein Isoforms
  • macroH2A histone