Receptor tyrosine kinases: genetic evidence for their role in Drosophila and mouse development

Trends Genet. 1990 Nov;6(11):350-6. doi: 10.1016/0168-9525(90)90276-c.


Receptor tyrosine kinases (RTKs) and their ligands are important components of the signalling pathways by which cells interact. This review summarizes a growing body of genetic evidence showing that many developmentally important mutations in Drosophila and the mouse are in the genes that encode RTKs or their ligands, indicating that these molecules play central roles during both invertebrate and vertebrate development.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Drosophila / enzymology
  • Drosophila / genetics*
  • Embryonic and Fetal Development / genetics*
  • Mice
  • Mutation
  • Protein-Tyrosine Kinases / genetics*
  • Protein-Tyrosine Kinases / metabolism
  • Receptors, Cell Surface / genetics*
  • Receptors, Cell Surface / metabolism
  • Signal Transduction


  • Receptors, Cell Surface
  • Protein-Tyrosine Kinases