Human leukocyte antigen-G polymorphism in relation to expression, function, and disease

Hum Immunol. 2009 Dec;70(12):1026-34. doi: 10.1016/j.humimm.2009.07.015. Epub 2009 Aug 6.

Abstract

Human leukocyte antigen-G (HLA-G) is a nonclassical class Ib molecule belonging to the major histocompatibility complex. HLA-G appears to play a role in the suppression of immune responses and contribute to long-term immune escape or tolerance. The focus of this review is polymorphism in the HLA-G gene and protein and its possible importance in expression, function, and disease associations.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • 3' Untranslated Regions / genetics
  • Alleles
  • Asthma / genetics
  • Autoimmune Diseases / genetics
  • Disease / genetics*
  • Exons / genetics
  • Female
  • HLA Antigens / classification
  • HLA Antigens / genetics*
  • HLA Antigens / physiology*
  • HLA-G Antigens
  • Histocompatibility Antigens Class I / classification
  • Histocompatibility Antigens Class I / genetics*
  • Histocompatibility Antigens Class I / physiology*
  • Humans
  • Linkage Disequilibrium
  • Organ Transplantation
  • Polymorphism, Genetic*
  • Pregnancy
  • Pregnancy Complications / genetics
  • Regulatory Sequences, Nucleic Acid

Substances

  • 3' Untranslated Regions
  • HLA Antigens
  • HLA-G Antigens
  • Histocompatibility Antigens Class I