A comparative review of laboratory-developed tests utilizing Invader HPV analyte-specific reagents for the detection of high-risk human papillomavirus

J Clin Virol. 2009 Jul;45 Suppl 1:S73-7. doi: 10.1016/S1386-6532(09)70011-3.

Abstract

Background: Testing for human papillomavirus (HPV) has emerged as an important component of cervical cancer screening and disease management. Analytic performance (sensitivity, specificity, positive predictive value, negative predictive value, accuracy) and clinical relevance are important criteria by which any new test must be reviewed.

Objective: This paper compares laboratory-developed tests, utilizing Invader analyte-specific reagents (ASRs) for the detection of oncogenic HPV DNA, to the Digene Hybrid Capture 2 test (HC2). In addition to accurately identifying the presence or absence of HPV, genotyping has emerged as an important consideration for risk stratification and patient management. This paper reviews all current relevant Invader HPV literature to explain how these results shape our current understanding of the topic.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • DNA, Viral / genetics*
  • DNA, Viral / isolation & purification
  • Female
  • Genotype
  • Humans
  • Molecular Diagnostic Techniques / methods*
  • Papillomaviridae / classification*
  • Papillomaviridae / isolation & purification*
  • Papillomavirus Infections / diagnosis*
  • Papillomavirus Infections / virology
  • Predictive Value of Tests
  • Sensitivity and Specificity
  • Virology / methods*

Substances

  • DNA, Viral