Antioxidant effect of polyphenolic glabridin on LDL oxidation

Toxicol Ind Health. 2009 May-Jun;25(4-5):321-4. doi: 10.1177/0748233709103034.

Abstract

This study was conducted to determine the effect of a natural polyphenolic isoflavone antioxidant (Glabridin) on low-density lipoprotein (LDL) oxidation. Determination of the extent of LDL oxidation was done by measuring the formation of Thiobarbituric acid reactive substances (TBARS). After oral administration of licorice-root ethanol extract to healthy subjects for 6 months, the subjects' oxidative stress level as well as plasma LDL oxidation reduced by 20%. We concluded that dietary consumption of glabridin protects LDL from oxidation.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Antioxidants / pharmacology*
  • Cholesterol, LDL / metabolism*
  • Cross-Over Studies
  • Double-Blind Method
  • Female
  • Flavonoids
  • Glycyrrhiza
  • Humans
  • Isoflavones / pharmacology*
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Oxidation-Reduction
  • Oxidative Stress / drug effects*
  • Phenols / pharmacology*
  • Plant Extracts / pharmacology
  • Plant Roots
  • Polyphenols
  • Thiobarbituric Acid Reactive Substances / metabolism

Substances

  • Antioxidants
  • Cholesterol, LDL
  • Flavonoids
  • Isoflavones
  • Phenols
  • Plant Extracts
  • Polyphenols
  • Thiobarbituric Acid Reactive Substances
  • glabridin