Abstract
This study was conducted to determine the effect of a natural polyphenolic isoflavone antioxidant (Glabridin) on low-density lipoprotein (LDL) oxidation. Determination of the extent of LDL oxidation was done by measuring the formation of Thiobarbituric acid reactive substances (TBARS). After oral administration of licorice-root ethanol extract to healthy subjects for 6 months, the subjects' oxidative stress level as well as plasma LDL oxidation reduced by 20%. We concluded that dietary consumption of glabridin protects LDL from oxidation.
Publication types
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Randomized Controlled Trial
MeSH terms
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Adult
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Aged
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Antioxidants / pharmacology*
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Cholesterol, LDL / metabolism*
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Cross-Over Studies
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Double-Blind Method
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Female
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Flavonoids
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Glycyrrhiza
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Humans
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Isoflavones / pharmacology*
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Longitudinal Studies
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Male
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Middle Aged
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Oxidation-Reduction
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Oxidative Stress / drug effects*
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Phenols / pharmacology*
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Plant Extracts / pharmacology
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Plant Roots
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Polyphenols
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Thiobarbituric Acid Reactive Substances / metabolism
Substances
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Antioxidants
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Cholesterol, LDL
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Flavonoids
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Isoflavones
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Phenols
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Plant Extracts
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Polyphenols
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Thiobarbituric Acid Reactive Substances
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glabridin