Abstract
Chemical investigation of the CH2Cl2 extract of the heartwood of Dalbergia candenatensis affored six new phenolic compounds, designated candenatenins A-F (1-6), as well as four known compounds, (2R,3R)-3,5-dihydroxy-7-methoxyflavanone (7), 4-hydroxy-3-methoxy-8,9-methylenedioxypterocarpan (8), nutiducol (9), and sophoraflavanone A (10). The structures of the new compounds were determined by 1D- and 2D-NMR spectroscopic studies as well as by MS analysis. The cytotoxic activities of the isolated compounds are also reported.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Dalbergia / chemistry*
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Drug Screening Assays, Antitumor
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Female
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HeLa Cells
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Humans
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KB Cells
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Phenols / chemistry
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Phenols / isolation & purification*
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Phenols / pharmacology
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Plants, Medicinal / chemistry*
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Stereoisomerism
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Structure-Activity Relationship
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Thailand
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Wood / chemistry
Substances
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Antineoplastic Agents, Phytogenic
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Phenols